Kajsheva Nelli Shalikovna,Кайшева Нелли Шаликовна,Kajshev Aleksandr Shalikovich,Кайшев Александр Шаликович,Mikelov Vladimir Aleksandrovich,Микелов Владимир Александрович
申请号：
RU2016116081
公开号：
RU0002630466C1
申请日:
2016.04.25
申请国别(地区):
RU
年份:
2017
代理人:
摘要：
FIELD: pharmacology.SUBSTANCE: invention relates to a method for preparation of an antioxidant drug in the form of pills based on biologically active compounds (BAC) of post-alcohol grain distilled dreg. First, effective antioxidant drug (pharmaceutical substance) "Biobaridin" is obtained from liquid and solid phases of post-alcohol grain distilled dreg by a known mehod (Pat. RF No. 2404766) in a powder form. The substance is then ground, powder fraction passed through a sieve with a hole diameter of 1.0 mm (sieve No. 10) and not passed through a sieve with a hole diameter of 0.5 mm (sieve No. 05) is selected, i.e. coarse powder with a particle size of 0.5-1.0 mm is selected. The selected substance fraction is mixed for 5 minutes with calcium hydrogen phosphate (filler), granulated with 10% alcohol solution of collidon-25 (binder), dried in a fluidized bed at a temperature of 40°C for 30 minutes (up to the residual granulate moisture content of 2.8%), dry granulate is passed through a sieve with a hole diameter of 1.5 mm (sieve No. 15), "powdered" with calcium stearate (lubricant) and pressed into "Biobardin" pills. The composition of one "Biobardin" pill weighing 0.21 g: "Biobardin" substance 0.16 g, calcium hydrophosphate 0.04 g, collidon-25 0.009 g (or 0.09 g of 10% collidon-25 alcohol solution), calcium stearate 0.001 g.EFFECT: development of the composition and technology of antioxidant pills based on biologically active compounds isolated from distilled dreg, possessing optimal parameters for pharmaceutical use, long shelf life.2 cl, 1 ex, 11 tblИзобретение относится к фармацевтической промышленности и касается способа получения антиоксидантного лекарственного препарата в форме таблеток на основе биологически активных соединений (БАС) послеспиртовой зерновой барды. Цель изобретения - разработка состава и технологии таблеток антиоксидантного действия на основе БАС, выделенных из барды, обладающих оптимальными для фармацевтического использования показателями: ор
