The present invention features methods of treating lung cancer (e.g., NSCLC) with an anti-PD-L1 antibody and a tyrosine kinase inhibitor in a subject identified as having an EGFR mutation-positive tumor.本發明提供在鑑別為患有EGFR突變陽性腫瘤的個體中用抗PD-L1抗體及酪胺酸激酶抑制劑治療肺癌(例如NSCLC)之方法。