MADDON PAUL J,MA DANGSHE,OLSON WILLIAM C,DORONINA SVETLANA O,TOKI BRIAN E,SENTER PETER D
申请号：
IN5063/KOLNP/2007
公开号：
IN265026B
申请日:
2007.12.27
申请国别(地区):
IN
年份:
2015
代理人:
摘要：
This invention relates generally to antibody-drag conjugates (ADCs). In particular the invention relates to ADCs which comprise an antibody or antigen-binding fragmentthereof which binds to prostate-specific membrane antigen (PSMA) and is conjugated tomonomethylauristatin norephedrine or monomethylauristatin phenylalanine. The antibody- drug conjugate has a PC-3™ cell to C4-2 or LNCaP™ cell selectivity of at least 250. Theinvention also relates, in part, to compositions of and methods of using the ADCs. Themethods provided include, for example, methods for treating a PSMA-mediated disease.
