JUHL, Karsten,TAGMOSE, Lena,MARIGO, Mauro,JENSEN, Thomas
申请号：
PE0002232018
公开号：
PE6962018A1
申请日:
2016.08.09
申请国别(地区):
PE
年份:
2018
代理人:
摘要：
This referred to the combined use of (an inhibitor of beta secretase BACE1 Enzyme Formula (1) wherein ar is phenyl, piridilo, pirimidilo,Among others r1 is alkyl or fluoroalquilo C1 - C3 C1 - C3 R2 is H, halogen, alkyl fluoroalquilo C1 - C3 and C1 - C3 R3 is C1 - C3 alkyl and a compound useful in the Immunotherapy of Tau active or passiveA compound useful in the Immunotherapy of Abeta Peptide active or passive, an antagonist of NMDA receptor, an inhibitor of acetylcholine esterase, an antiepileptic Drug, an anti-inflammatory Drug,An inhibitor of Aggregation of Tau or an SSRI for the treatment of Cognitive or neurodegenerative disorders, such as Alzheimers diseaseEsta referido al uso combinado de un inhibidor de BACE1 (enzima beta-secretasa 1) de formula I en donde Ar es fenilo, piridilo, pirimidilo, entre otros R1 es alquilo C1-C3 o fluoroalquilo C1-C3 R2 es H, halogeno, fluoroalquilo C1-C3 o alquilo C1-C3 R3 es alquilo C1-C3 y un compuesto util en la inmunoterapia de Tau activa o pasiva, un compuesto util en la inmunoterapia de peptido Abeta activa o pasiva, un antagonista de receptor de NMDA, un inhibidor de acetilcolina esterasa, un antiepileptico, un farmaco antiinflamatorio, un inhibidor de la agregacion de Tau o un SSRI para el tratamiento de trastornos neurodegenerativos o cognitivos, tal como enfermedad de Alzheimer
