Ko Nakamura,Yoshitaka Nakazawa,Minoru Kawamura,Kunihiko Higashiura,Tomoshi Miura
申请号：
US12087591
公开号：
US08236844B2
申请日:
2007.01.23
申请国别(地区):
US
年份:
2012
代理人:
摘要：
A novel histidine derivative represented by the following formula (I), and a pharmaceutically acceptable salt and hydrate thereof, useful as a pharmaceutical agent such as analgesics for the treatment of various kinds of acute or chronic pain diseases and of neuropathic pain diseases:wherein, R1 is hydrogen, alkyl having 1 to 6 carbon(s) or benzyl which may be substituted with alkyl having 1 to 4 carbon(s) or halogen R2 is hydrogen or alkyl having 1 to 4 carbon(s) R3 and R4 are same or different and each is hydrogen, alkyl having 1 to 4 carbon(s) or phenyl which may be substituted with any one or two of alkyl having 1 to 6 carbon(s), alkoxy having 1 to 6 carbon(s), halogen, trifluoromethyl, nitro and cyano and R5 is hydrogen or an alkyl group having 1 to 4 carbon(s).
