Pierfrancesco TASSONE,Pierosandro TAGLIAFERRI,Maria Teresa Di Martino
申请号：
US15535018
公开号：
US20180051284A1
申请日:
2015.12.04
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention refers to inhibitors of the miR-17-92 cluster and to their use as medicaments, in particular in the treatment of multiple myeloma and other malignancies. More in particular, the present invention refers to an LNA/DNA gapmer which binds to a region of the primary miRNA (pri-miRNA) of the miR-17-92 cluster Said inhibitors can be used for the treatment of tumors related to an overexpression of any of the miRNAs of the miR-17-92 cluster. Pharmaceutical compositions are also within the scope of the invention.
