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THERAPEUTIC AGENT FOR CARDIOMYOPATHY, OLD MYOCARDIAL INFARCTION AND CHRONIC HEART FAILURE
专利权人:
OSAKA UNIVERSITY;StemRIM Inc.
发明人:
Katsuto TAMAI,Yoshiki SAWA,Shigeru MIYAGAWA,Takashi KIDO,Takasumi GOTO,Takehiko YAMAZAKI
申请号:
US16477878
公开号:
US20190343924A1
申请日:
2018.01.26
申请国别(地区):
US
年份:
2019
代理人:
摘要:
The present inventors have found that HMGB1 fragment peptides having a particular amino acid sequence exhibit the effects of improvement of cardiac function, inhibition of cardiomyocyte hypertrophy, inhibition of myocardial fibrosis, and promotion of angiogenesis in an animal model of dilated cardiomyopathy, that the particular HMGB1 fragment peptides also exhibit the effects of improvement of cardiac function, inhibition of cardiomegaly, inhibition of cardiomyocyte hypertrophy, inhibition of myocardial fibrosis, and promotion of angiogenesis in an animal model of ischemic cardiomyopathy caused by old myocardial infarction, and that the particular HMGB1 fragment peptides exhibit the effects of inhibition of cardiomyocyte hypertrophy and inhibition of myocardial fibrosis in an animal model of hypertensive cardiomyopathy. Based on these findings, pharmaceutical compositions are provided for the prevention and/or treatment of cardiomyopathy and old myocardial infarction and chronic heart failure resulting therefrom, which comprise an HMGB1 fragment peptide having a particular amino acid sequence.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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