The present disclosure relates approaches for removing or reducing the effects of motion in parallel and non-parallel data acquisitions using a nuclear medicine imaging system. In certain embodiments, translation vectors (130) are derived based on a registration (120) performed on transaxial slices (116) generated from the acquired projection data (104). The translation vectors (130) may be employed to update (142) a system matrix (11 0) such that images generated using the updated system matrix (144) are free or motion artifacts or have reduced motion artifacts.
