BEUSKER PATRICK HENRY,COUMANS RUDY GERARDUS ELISABETH,ELGERSMA RONALD CHRISTIAAN,MENGE WIRO MICHAEL PETRUS BERNARDUS,JOOSTEN JOHANNES ALBERTUS FREDERIKUS,SPIJKER HENRI JOHANNES,DE GROOT FRANCISCUS MAR
申请号：
ZA201208282
公开号：
ZA201208282B
申请日:
2012.11.05
申请国别(地区):
ZA
年份:
2014
代理人:
摘要：
This invention relates to novel conjugates of the DNA-alkylating agent CC-1065. The conjugates are designed to release their (multiple) payload after one or more activation steps and/or at a rate and time span controlled by the conjugate in order to selectively deliver and/or controllably release one or more of said DNA alkylating agents. The conjugates can be used to treat an illness that is characterized by undesired (cell) proliferation. As an example, the conjugates of this invention may be used to treat a tumor.
