CORREIA, IVAN R.,RADZIEJEWSKI, CZESLAW H.,FRAUNHOFER, WOLFGANG,WARNE, NICHOLAS W.,KANTOR, ANGELA
申请号：
EP09829752
公开号：
EP2350649A4
申请日:
2009.11.24
申请国别(地区):
EP
年份:
2012
代理人:
摘要：
The invention provides compositions and methods for inhibiting fractionation of immunoglobulins comprising a lambda light chain based on the observation that iron, in the presence of histidine, results in increased fragmentation of a recombinant fully human IgG molecule containing a lambda light chain due to cleavage in the hinge region. The invention further provides an aqueous pharmaceutical formulation comprising an antibody, or antigen-binding portion thereof, that binds the p40 subunit of IL-12/IL-23 and a buffer system comprising histidine, wherein the formulation has enhanced stability, including enhanced resistance to fragmentation.
