The membrane of the human or animal body , and an apparatus for drilling to introduce the liquid formulation therein ( 10,20,30,40,50,60 ) , the device , distal door includes a proximal side , and a base surface with a plurality of projections ( 11, 21, 31 ) ( 12, 22 ) , each projection is arranged to pierce the membrane from the distal side of the base surface protruding up to the end ( 13, 23, 33 ) , each projection ( 11, 21, 31 ) is proximal - the cross-sectional dimension that varies along the distal shaft , outside and surrounding the hollow portion at the distal side of the shell ( includes a hollow portion ( 14, 24, 34 ) and with the 111, 211, 311 ) , is opened toward the proximal side of the base surface is hollow , outer shell ( 111, 211, 311 ) and base surface ( 12 , 22, 32 ) is made from polymeric material , substantially has a constant thickness between the outer shell ( 111, 211, 311 ) of the base surface and the tip of the liquid formulation from the hollow portion to the distal in one hole for the passage of objects ( 15, 25, 35 ) is provided on the outer shell ( 111, 211, 311 ) inside is offset from the tip ( 13, 23, 33 ) , the projections ( 11, 21 , 31) , is emitted from the hollow portion ( 14, 24, 34 ) comprises a subsequent fluid passageway ( 150 ) through the outer shell ( 111, 211, 311 ) up to the holes ( 15, 25, 35 ) , the fluid passage , the proximal - I is characterized by being oriented at an angle relative to the distal axis ( 16, 160 ) . [ Selection Figure ] Figure 5人間または動物の体の膜に、その中に液体配合物を導入するように穴をあけるための装置(10,20,30,40,50,60)であって、その装置が、遠位側と近位側、及び複数の突起(11,21,31)を持つベース表面(12,22,32)を含み、各突起が、ベース表面の遠位側から膜に穴をあけるために配置された先端(13,23,33)に至るまで突出し、各突起(11,21,31)が、近位-遠位軸に沿って変わる断面寸法と、遠位側で中空部を囲む外殻(111,211,311)を持つ中空部(14,24,34)とを含み、中空部がベース表面の近位側に向かって開放し、外殻(111,211,311)及びベース表面(12,22,32)が高分子材料から作られ、外殻(111,211,311)がベース表面と先端の間に実質的に一定の厚さを持ち、中空部から遠位側への液体配合物の通過のための穴(15,25,35)が、先端(13,23,33)から片寄って外殻(111,211,311)内に設けられているものにおいて、突起(11,21,31)が、中空部(14,24,34)から発出し、外殻(111,21
