Bispecifc binding molecules binding to both VEGF and Ang2, preferably in the form of immunoglobulin single variable domains like VHHs and domain antibodies, pharmaceutical compositions containing the same and their use in the treatment of diseases that are associated with VEGF- and/or Ang2-mediated effects on angiogenesis are disclosed. Further, nucleic acids encoding bispecific binding molecules, host cells and methods for preparing same are also described.本發明揭示結合VEGF與Ang2之雙特異性結合分子，其較佳呈如VHH及域抗體之免疫球蛋白單可變域的形式；含有該等分子之醫藥組合物及其於治療與VEGF及/或Ang2介導之對血管生成的作用相關之疾病中之用途。此外，本發明亦描述編碼雙特異性結合分子之核酸，宿主細胞及其製備方法。
