University of Louisville Research Foundation; Inc.
发明人:
Claudio Maldonado,Craig McClain,Shirish S. Barve,Leila Gobejishvili,Philip Bauer
申请号：
US16347908
公开号：
US20190275003A1
申请日:
2017.11.08
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Provided herein are compositions for treating liver inflammation. The compositions include a biologically active phosphodiesterase 4 (PDE4) inhibitor and a liposome, the liposome encapsulating the PDE4 inhibitor. The liposome may be anionic and include both neutrally charged and negatively charged phospholipids. Encapsulation of the PDE4 inhibitor in the liposome facilitates targeted delivery to the liver while limiting access to the central nervous system.
