SUPURAN, CLAUDIU,DEDHAR, SHOUKAT,CARTA, FABRIZIO,WINUM, JEAN-YVES,MCDONALD, PAUL C.
申请号：
CA2856812
公开号：
CA2856812A1
申请日:
2011.11.25
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
Compositions for the treatment of cancer comprising coumarin and thiocoumarin derivatives of Formulas I- XII are disclosed. Said derivatives preferentially inhibit carbonic anhydrase IX and XII (which are associated with hypoxic and metastatic tumours) over inhibiting carbonic anhydrase I and II activity. The compositions therefore are suited for treatment of hypoxic or metastatic cancers due to this selective mechanism of action.
