Towards a thorough understanding of mammalian glycosylphosphatidylinositol-anchored protein biosynthesis

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作   者：

Kinoshita, Taroh; 

作者机构：

Osaka Univ;  Osaka University; 

关键词：

ANALYSIS REVEALS;  glycosyltransferases;  ATTACHMENT;  OMEGA-SITE;  GPI-ANCHOR;  EXPRESSION CLONING;  SACCHAROMYCES-CEREVISIAE;  ER;  Golgi apparatus;  TRANSAMIDASE;  YEAST ARV1;  biosynthesis pathway;  glycosylphosphatidylinositol (GPI);  PIG-T;  endoplasmic reticulum; 

期刊名称：

Glycobiology.

i s s n：

0959-6658

年卷期：

2024 年 34 卷 11 期

页   码：

cwae061-cwae061

页   码：

摘   要：

Glycosylphosphatidylinositols (GPIs) are glycolipids found ubiquitously in eukaryotes. They consist of a glycan and an inositol phospholipid, and act as membrane anchors of many cell-surface proteins by covalently linking to their C-termini. GPIs also exist as unlinked, free glycolipids on the cell surface. In human cells, at least 160 proteins with various functions are GPI-anchored proteins. Because the attachment of GPI is required for the cell-surface expression of GPI-anchored proteins, a thorough knowledge of the molecular basis of mammalian GPI-anchored protein biosynthesis is important for understanding the basic biochemistry and biology of GPI-anchored proteins and their medical significance. In this paper, I review our previous knowledge of the biosynthesis of mammalian GPI-anchored proteins and then examine new findings made since 2020.