Chronic Spontaneous Urticaria: The Role and Relevance of Autoreactivity, Autoimmunity, and Autoallergy

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作   者：

Asero, Riccardo;  Ferrer, Marta;  Kocaturk, Emek;  Maurer, Marcus; 

作者机构：

Dept Allergy;  Inst Allergol;  Univ Navarra Clin;  Koc Univ;  Charite Univ Med Berlin;  Sch Med;  Ambulatorio Allergol;  Clin San Carlo; 

关键词：

Autoimmunity;  OMALIZUMAB;  FC-EPSILON-RI;  ASSOCIATIONS;  CHRONIC IDIOPATHIC URTICARIA;  REACTIVITY;  HISTAMINE-RELEASE;  Autoreactivity;  AUTOLOGOUS SERUM;  Chronic urticaria;  ANTI-IGE AUTOANTIBODIES;  BASOPHILS;  SERUM SKIN-TEST; 

期刊名称：

The journal of allergy and clinical immunology. In practice.

i s s n：

2213-2198

年卷期：

2023 年 11 卷 8 期

页   码：

2302-2308

页   码：

摘   要：

Chronic spontaneous urticaria (CSU) is a frequent and often severely disabling disease. A large number of studies were performed during the last 2 decades to clarify its pathogenesis. These studies shed light on the underlying autoimmune mechanisms of CSU pathogenesis and have led us to understand that different mechanisms may exist and, sometimes, coexist behind the same clinical presentation. The present article reviews the meaning of the terms autoreactivity, autoimmunity, and autoallergy, which have been variably used over the years to define different endotypes of the disease. Furthermore, we discuss the methods potentially able to lead us to the correct classification of CSU patients.