Comparison of coccidioidal complement fixation and quantitative immunodiffusion serology at a reference laboratory

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作   者：

Zhang, Kaihua;  Bays, Derek J.;  Cohen, Stuart H.;  Wilson, Machelle D.;  Thompson III, George R.;  Bryan Jr, Allen W.;  Sykes, Jane;  Crucillo, Kelly; 

作者机构：

Davis;  Tupper Hall 3146;  CA 95616 USA;  CA 95616 USAUniversity of California Davis;  CA 95616 USAUniversity of California Davis School;  UC Davis One Shields Ave; 

关键词：

serology;  quantitative immunodiffusion;  Coccidioides;  prognosis; 

期刊名称：

Medical mycology :

i s s n：

1369-3786

年卷期：

2024 年 62 卷 1 期

页   码：

myad121-myad121

页   码：

摘   要：

The incidence of coccidioidomycosis continues to increase. The diagnosis frequently relies on non-invasive diagnostic testing with immunodiffusion and complement fixation (CF) testing the current gold standard. A direct comparison of quantitative immunodiffusion and CF for IgG antibodies has not been previously reported. In a comparison of 368 samples, there was close concordance observed (360/368 = 97.8%) (P-value < .001). These tests can be considerably interchangeable in the reference laboratory setting.