Abnormal changes of dynamic topological characteristics in patients with major depressive disorder

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作   者：

Zhou, Yue;  Zhu, Yihui;  Ye, Hongting;  Jiang, Wenhao;  Zhang, Yubo;  Kong, Youyong;  Yuan, Yonggui;  Rest meta MDD Consortium; 

作者机构：

Jinan Med Ctr Management CommShandong Univ Shandong University Cheeloo Coll Med Sch Publ Hlth Dept; 

关键词：

Functional connectivity;  THALAMUS;  VOLUME;  FUNCTIONAL CONNECTIVITY;  Graph theory;  DYSFUNCTION;  Dynamic topological characteristics;  ORBITOFRONTAL CORTEX;  Major depressive disorder;  BRAIN; 

期刊名称：

Journal of affective disorders

i s s n：

0165-0327

年卷期：

2024 年 345 卷

页   码：

349-357

页   码：

摘   要：

Background: Most studies have detected abnormalities of static topological characteristics in major depressive disorder (MDD). However, whether dynamic alternations in brain topology are influenced by MDD remains unknown.Methods: An approach was proposed to capture the dynamic topological characteristics with sliding-window and graph theory for a large data sample from the REST-meta-MDD project.Results: It was shown that patients with MDD were characterized by decreased nodal efficiency of the left orbitofrontal cortex. The temporal variability of topological characteristics was focused on the left opercular part of inferior frontal gyrus, and the right part of middle frontal gyrus, inferior parietal gyrus, precuneus and thalamus. Limitations: Future studies need larger and diverse samples to explore the relationship between dynamic topo-logical network characteristics and MDD symptoms.Conclusions: The results support that the altered dynamic topology in cortex of frontal and parietal lobes and thalamus during resting-state activity may be involved in the neuropathological mechanism of MDD.