KINETIC STUDIES OF FLUOROCURCUMIN DERIVATIVES WITH ANTICANCER ACTIVITY

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作   者：

Ku?mińska, Joanna;  Muszalska-Kolos, Izabela;  Jankowska, Weronika;  Goslinski, Tomasz;  Jelińska, Anna;  Sobczak, Agnieszka; 

作者机构：

Grunwaldzka 6;  Department of Pharmaceutical Chemistry;  Pozna;  Poznań University of Medical Sciences; 

关键词：

degradation;  fluorocurcumin derivative;  kinetic studies;  HPLC;  validation; 

期刊名称：

Acta Poloniae Pharmaceutica: Durg Research

i s s n：

0001-6837

年卷期：

2023 年 80 卷 2 期

页   码：

235-244

页   码：

摘   要：

Two novel fluorocurcumin adducts with a difluoroboryl group exhibited activity in vitro against two bladder cancer cell lines, namely 5637 and SCaBER. The stability was evaluated under physiologically relevant conditions to mimic both the digestive tract and the bladder environment. Therefore, experiments were performed in hydrochloric acid at pH 1.2, and in buffer solutions with pH from 4.5 to 6.8 at 37°C. A validated HPLC method, allowing the monitoring of changes in substrates and product concentrations over time, was applied. Notably, the main decomposition product was the fluorocurcumin derivative without the difluoroboryl group. The decomposition of the fluorocurcumin adducts to the major products undergoes the pseudo-first-order kinetics reaction. ? 2023 by Polish Pharmaceutical Society.