Mild Photothermal‐Stimulation Based on Injectable and Photocurable Hydrogels Orchestrates Immunomodulation and Osteogenesis for High‐Performance Bone Regeneration

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作   者：

Minhao Wu;  Huifan Liu;  Yufan Zhu;  Feixiang Chen;  Zhe Chen;  Liangyu Guo;  Ping Wu;  Gailing Li;  Chong Zhang;  Renxiong Wei;  Lin Cai; 

作者机构：

Renmin Hospital of Wuhan University;  Wuhan University;  Huazhong University of Science and Technology;  Zhongnan Hospital of Wuhan University;  Chinese Academy of Medical Science; 

关键词：

immunomodulation;  bone regeneration;  multifunctional hydrogels;  osteogenesis;  mild photothermal therapy; 

期刊名称：

Small

i s s n：

1613-6810

年卷期：

2023 年 19 卷 28 期

页   码：

n/a-n/a

页   码：

摘   要：

Abstract A photoactivated bone scaffold integrated with minimally invasive implantation and mild thermal‐stimulation capability shows great promise in the repair and regeneration of irregularly damaged bone tissues. Developing multifunctional photothermal biomaterials that can simultaneously serve as both controllable thermal stimulators and biodegradable engineering scaffolds for integrated immunomodulation, infection therapy, and impaired bone repair remains an enormous challenge. Herein, an injectable and photocurable hydrogel therapeutic platform (AMAD/MP) based on alginate methacrylate, alginate‐graft‐dopamine, and polydopamine (PDA)‐functionalized Ti3C2 MXene (MXene@PDA) nanosheets is rationally designed for near‐infrared (NIR)‐mediated bone regeneration synergistic immunomodulation, osteogenesis, and bacterial elimination. The optimized AMAD/MP hydrogel exhibits favorable biocompatibility, osteogenic activity, and immunomodulatory functions in vitro. The proper immune microenvironment provided by AMAD/MP could further modulate the balance of M1/M2 phenotypes of macrophages, thereby suppressing reactive oxygen species‐induced inflammatory status. Significantly, this multifunctional hydrogel platform with mild thermal stimulation efficiently attenuates local immune reactions and further promotes new bone formation without the addition of exogenous cells, cytokines, or growth factors. This work highlights the potential application of an advanced multifunctional hydrogel providing photoactivated on‐demand thermal cues for bone tissue engineering and regenerative medicine.