Synthesis of Pyridine-SF4-Alkynes via Light-Promoted Radical Coupling of Pyridine-SF4-Chlorides and EBX Reagents

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作   者：

Mahmoud, Elsayed M.;  Iwasaki, Hiroto;  Hada, Kenshiro;  Murata, Yusuke;  Sumii, Yuji;  Shibata, Norio; 

作者机构：

Nagoya Inst Technol; 

关键词：

Tetrafluoro-?6-sulfanyl;  PYRIDINE;  Irradiation;  CHLORIDES;  ARYL;  ALKYNES;  Ethynylbenziodoxolone;  ALKYNYLATION;  MOTIF; 

期刊名称：

Bulletin of the Chemical Society of Japan

i s s n：

0009-2673

年卷期：

2023 年 96 卷 2 期

页   码：

110-112

页   码：

摘   要：

Pyridine-tetrafluoro-lambda 6-sulfanyl-alkynes have emerged as building blocks for synthesizing linearly-linked pyridine -hetero-cycles. They are prepared via a two-step procedure comprising the radical addition of pyridine-tetrafluoro-lambda 6-sulfanyl-chlorides and alkynes and subsequent base-promoted elimination of HCl. Herein we developed a straightforward alternative synthesis via the radical coupling of pyridine-tetrafluoro-lambda 6-sulfanyl-chlorides with ethynylbenziodoxolone reagents under LED irradiation.