Radical Arylaminoformylation of Activated Alkenes to Amides Containing All‐Carbon Quaternary Stereocenters

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作   者：

Jing Liu;  Baohui Zhang;  Junjie Hu;  Zhenpeng Qiu;  Xinyan Chen;  Xianxiang Tian;  Qi Wang;  Guohua Zheng;  Ming Yuan; 

作者机构：

Hubei University of Chinese Medicine; 

关键词：

olefin difunctionalization;  radical smiles rearrangement;  aminoformylation;  succinyl diamides;  all-carbon quaternary stereocenter; 

期刊名称：

European journal of organic chemistry

i s s n：

1434-193X

年卷期：

2023 年 26 卷 6 期

页   码：

n/a-n/a

页   码：

摘   要：

Abstract Herein we report an Ag+/S2O82− inducted measure for functionalized succinyl diamides bearing an all‐carbon quaternary stereocenter via a radical aminoformylation/aryl‐migration/desulfonylation cascade. The improved process is developed employing readily available and inexpensive oxalic monoamide as a carbamoyl radical precursor through radical Smiles rearrangement. Additionally, the tolerance to oxygen and water, operational simplicity, convenient reagents, as well as scalability, enhance the practical value of the proposed synthesis strategy.