Epstein-Barr virus: Biology and clinical disease

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作   者：

Damania, Blossom;  Kenney, Shannon C.;  Raab-Traub, Nancy; 

作者机构：

Univ North Carolina Chapel Hill;  Univ Wisconsin Madison; 

关键词：

REED-STERNBERG CELLS;  NASOPHARYNGEAL CARCINOMA;  MEMBRANE-PROTEIN 1;  LYMPHOPROLIFERATIVE DISEASE;  TOLL-LIKE RECEPTOR;  GENE-EXPRESSION;  RIG-I;  EPHRIN RECEPTOR A2;  GROWTH-FACTOR;  NF-KAPPA-B; 

期刊名称：

Cell

i s s n：

0092-8674

年卷期：

2022 年 185 卷 20 期

页   码：

3652-3670

页   码：

摘   要：

Epstein-Barr virus (EBV) is a ubiquitous, oncogenic virus that is associated with a number of different human malignancies as well as autoimmune disorders. The expression of EBV viral proteins and non-coding RNAs contribute to EBV-mediated disease pathologies. The virus establishes life-long latency in the human host and is adept at evading host innate and adaptive immune responses. In this review, we discuss the life cycle of EBV, the various functions of EBV-encoded proteins and RNAs, the ability of the virus to activate and evade immune responses, as well as the neoplastic and autoimmune diseases that are associated with EBV infec-tion in the human population.