A practical approach to the optimization of positron emission tomography imaging agents for the central nervous system

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作   者：

Yves P. Auberson;  Akané Lièvre;  Sandrine Desrayaud;  Emmanuelle Briard; 

作者机构：

Novartis Institutes for BioMedical Research; 

关键词：

optimization;  positron emission tomography;  imaging;  imaging agent properties; 

期刊名称：

Journal of labelled compounds & radiopharmaceuticals.

i s s n：

0362-4803

年卷期：

2022 年 65 卷 13 期

页   码：

343-350

页   码：

摘   要：

The discovery of novel imaging agents for positron emission tomography (PET) relies on medicinal chemistry best practices, including a good understanding of molecular and pharmacological properties required for the acquisition of relevant, high‐quality images. This short note reviews the characteristics of a series of clinically successful imaging agents, providing guidance for the optimization of such molecular tools. PET imaging plays an important role in staging disease and in helping clinical dose selection, which is critical for the efficient development of drug candidates.