Gastroprotective and Antioxidant Properties of Trigonella foenum graecum Seeds Aqueous Extract (Fenugreek) and Omeprazole Against Ethanol-Induced Peptic Ulcer

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作   者：

Selmi, Slimen;  Alimi, Dhouha;  Rtibi, Kais;  Jedidi, Saber;  Grami, Dhekra;  Marzouki, Lamjed;  Hosni, Karim;  Sebai, Hichem; 

作者机构：

Higher Inst Biotechnol Beja;  Natl Inst Res & Physico Chem Anal INRAP;  Univ Jendouba;  Sylvo Pastoral Inst Tabarka;  Lab Nat Subst; 

关键词：

DEFENSE;  OXIDATIVE STRESS;  PROTEIN;  rat;  BARRIER;  TISSUE;  TOXICITY;  fenugreek seeds;  OFFICINALIS;  POLYPHENOLS;  MODELS;  inflammation;  peptic ulcer;  PLANTS;  oxidative stress; 

期刊名称：

Journal of medicinal food

i s s n：

1096-620X

年卷期：

2022 年 25 卷 5 期

页   码：

513-522

页   码：

摘   要：

Trigonella foenum graecum (Fenugreek) is used in traditional phytomedicine for its anti-inflammatory, antiseptic, antidiabetic, and several other therapeutic virtues. The current study was intended to investigate the protecting effects of fenugreek seeds' aqueous extract (FSAE) using experimentally ethanol (EtOH)-induced gastric peptic ulcer in rats, as immense alcohol consumption can lead to gastric ulcer. Sixty adult male Wistar rats were divided into 6 groups of 10 each: control, EtOH (4 g/kg body weight [b.w.]), EtOH + several doses of FSAE (50, 100, and 200 mg/kg b.w.), and EtOH + Omeprazole (OM, 20 mg/kg orally [p.o.]). Animals were p.o. pretreated with FSAE for 21 days and exposed to a single oral administration of EtOH (4 g/kg b.w.) for 2 h. Gastric ulcer in rats was induced with a single dose of EtOH. Ulcer index, malondialdehyde (MDA), hydrogen peroxide (H2O2), and thiol groups (-SH) content in stomach, and antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) were measured. Our recorded results showed that EtOH induced gastric damage, evidenced by the level of oxidative stress markers such as MDA and H2O2 in rats exposed to EtOH. However, significant increases in the activities of antioxidant enzymes were recorded, such as SOD, CAT, and GPx, and a decrease in nonenzymatic antioxidants, such as (-SH). Moreover, histopathological examinations showed the presence of lesions associated with severe tissue damage in the untreated rats. Interestingly, FSAE meaningfully protects against all gastric damages caused by EtOH. We propose that FSAE exhibits protective effects in EtOH-induced peptic ulcer in rats. This protection might be related to its antioxidant and anti-inflammatory properties as well as its opposite effects on some studied intracellular mediators.