An updated review of mesoporous carbon as a novel drug delivery system

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作   者：

Attia, Mohamed S.;  Hassaballah, Mohamed Y.;  Abdelqawy, Mohab A.;  Emad-Eldin, Mahmoud;  Farag, Aya K.;  Negida, Ahmed;  Ghaith, Hazem;  Emam, Sherif E.; 

作者机构：

Zagazig Univ Hosp;  Al Azhar Univ;  Fac Pharm;  Fac Med;  Dept Pharm Practice;  Zagazig Univ;  Dept Pharmaceut; 

关键词：

IMPROVE;  biocompatibility;  Mesoporous carbon;  DOXORUBICIN;  CONTROLLED-RELEASE;  drug delivery;  NANOCAPSULES;  stimuli-responsive;  CARRIER;  NANOPARTICLES;  controlled release;  nanoparticles;  DISSOLUTION;  ORAL BIOAVAILABILITY;  NANOSPHERES;  SILICA; 

期刊名称：

Drug development and industrial pharmacy

i s s n：

0363-9045

年卷期：

2021 年 47 卷 7 期

页   码：

1029-1037

页   码：

摘   要：

The nanotechnology approach has been recently adopted to provide more reliable, effective, controlled, and safe drug delivery systems. Nanostructured materials have gained great interest, including siliceous and carbonaceous nanoparticles. The effectiveness of mesoporous carbon nanoparticles (MCNs) in tumor imaging, targeting, and treatment is urging for more future studies. MCNs possess superior properties such as their biocompatibility, large surface area, large pore volume, tunability, and more responsive behavior to internal and external release triggers. These outstanding features make MCNs more applicable for stimuli-responsive drug delivery than the conventional forms of mesoporous silica nanoparticles (MSNs) and other carbon nanoparticles. In this review, we outlined the latest updates regarding the safety, benefits, and potential applications of MCNs.