The Relationship of Age and Hypertension With Cognition and Gray Matter Cerebral Blood Volume in a Rhesus Monkey Model of Human Aging

• 全文链接
• 请求原文

作   者：

Farris, Chad W.;  Killiany, Ronald J.;  O'Donoghue, Elizabeth;  Koo, Bang-Bon;  Wainford, Richard D.;  Moss, Mark B.;  Rosene, Douglas L.;  Moore, Tara L.; 

作者机构：

Boston Univ; 

关键词：

EXECUTIVE SYSTEM DYSFUNCTION;  magnetic resonance imaging;  DEMENTIA;  LONGITUDINAL CHANGES;  RATS;  FLOW;  DECLINE;  IMPAIRMENT;  rhesus monkey;  PRESSURE;  cerebral blood volume;  RECOGNITION MEMORY;  hypertension;  BRAIN;  executive function; 

期刊名称：

Behavioral neuroscience

i s s n：

0735-7044

年卷期：

2021 年 135 卷 5 期

页   码：

680-692

页   码：

摘   要：

The goal of this study was to investigate whether alterations in cerebral microvasculature, as measured by cerebral blood volume (CBV), contribute to age- and hypertension-related impairments in cognitive function with a focus on executive function and memory. Data were collected on 19 male rhesus monkeys ranging from 6.4 to 21.6 years of age. Hypertension was induced through surgical coarctation of the thoracic aorta. We assessed whether performance on tasks of memory and executive function corresponded to CBV in either the hippocampus or prefrontal cortex. We found a relationship between duration of hypertension and CBV in the gray matter of the prefrontal cortex, but not the hippocampus. No relationships were found with the degree of hypertension or age. Increased prefrontal CBV was related to greater impairment in executive function while hippocampal CBV was not related to memory performance. These findings suggest that duration, but not severity, of hypertension or age are important factors underlying alterations in brain microvasculature and that executive function is more vulnerable than memory function.