Molecular detection of extensively drug-resistant Salmonella Typhi and carbapenem-resistant pathogens in pediatric septicemia patients in Pakistan?–?a public health concern

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作   者：

Muhammad Usman Qamar;  Atifa Ambreen;  Alia Batool;  Muhammad Hidayat Rasool;  Muhammad Shafique;  Adnan Khan;  Muhammad Atif Nisar;  Anam Khalid;  Kashaf Junaid;  Khalid Omer Abdalla Abosalif;  Hasan Ejaz; 

作者机构：

Government College University?Faisalabad;  Fatima Memorial Hospital;  Jouf University;  University of Karachi;  College of Applied Medical Sciences;  Department of Clinical Laboratory Sciences;  Faculty of Life Sciences;  Department of Pathology;  Department of Microbiology; 

关键词：

septicemia;  children;  XDR Salmonella Typhi;  carbapenem resistant; 

期刊名称：

Future microbiology

i s s n：

1746-0913

年卷期：

2021 年 16 卷 10 期

页   码：

731-739

页   码：

摘   要：

Aim: To determine the prevalence of multidrug (MDR) and extensively drug-resistant (XDR) pathogens from pediatric blood samples Methods: In total, 4543 children's blood samples were processed in the BacT/ALERT system. Confirmation of the isolates and MIC was determined in VITEK??2?system. Molecular identification of blaIMP, blaVIM and blaOXA-48 was done by PCR. Results: Of 4543 blood cultures, 458 (10%) were positive for bacterial growth and Salmonella?Typhi (415; 90%) remained the primary pathogens. Antibiogram revealed 208 (50.1%) and 137 (33%) were MDR and XDR S. Typhi, respectively. Klebsiella pneumoniae displayed 46% resistance to imipenem. One hundred twelve (81.7%) XDR Typhi were positive for blaCTXM, whereas 14 (66.6%) blaVIM were found in carbapenem-resistant bacteria. Conclusion:?A high prevalence of MDR and XDR pathogens?was found in peads blood culture.