Deguelin targets multiple oncogenic signaling pathways to combat human malignancies

• 全文链接
• 请求原文

作   者：

Tuli, Hardeep Singh;  Mittal, Sonam;  Loka, Mariam;  Aggarwal, Vaishali;  Aggarwal, Diwakar;  Masurkar, Akshara;  Kaur, Ginpreet;  Varol, Mehmet;  Sak, Katrin;  Kumar, Manoj;  Sethi, Gautam;  Bishayee, Anupam; 

作者机构：

TR-48000 Mugla;  EE-50407 Tartu;  Fac Sci;  Shobhaben Pratapbhai Patel Sch Pharm & Technol Ma;  Pittsburgh;  Bradenton;  NGO Praeventio;  PA 15260 USA;  Mugla Sitki Kocman Univ;  Singapore;  Maharishi Markandeshwar Deemed Univ;  Yong Loo Lin Sch Med;  Jawaharlal Nehru Univ;  India;  Dept Mol Biol & Genet;  5000 Lakewood Ranch Blvd;  Turkey;  Dept Pharmacol;  Dept Pharmaceut Sci;  Singapore 117600;  Mullana Ambala 133207;  Lake Erie Coll Osteopath Med;  New Delhi 110067;  Sch Biotechnol;  Dept;  FL 34211 USA;  Dept Biotechnol;  Dept Chem;  Sadopur 134007;  Natl Univ Singapore;  Univ Pittsburgh;  Narsee Monjee Inst Management Studies Univ;  Estonia;  Haryana; 

关键词：

Antiproliferation;  Deguelin;  Angiogenesis inhibition;  Metastasis inhibition;  Apoptotic;  Anti-inflammation; 

期刊名称：

Pharmacological research: The official journal of The Italian Pharmacological Society

i s s n：

1043-6618

年卷期：

2021 年 166 卷

页   码：

摘   要：

Cancer is an anomalous growth and differentiation of cells known to be governed by oncogenic factors. Plant-based natural metabolites have been well recognized to possess chemopreventive properties. Deguelin, a natural rotenoid, is among the class of bioactive phytoconstituents from a diverse range of plants with potential antineoplastic effects in different cancer subtypes. However, the precise mechanisms of how deguelin inhibits tumor progression remains elusive. Deguelin has shown promising results in targeting the hallmarks of tumor progression via inducing tumor apoptosis, cell cycle arrest, and inhibition of angiogenesis and metastasis. Based on initial scientific excerpts, deguelin has been reported to inhibit tumor growth via different signaling pathways, including mitogen-activated protein kinase, phosphoinositide 3-kinase, serine/threonine protein kinase B (also known as Akt), mammalian target of rapamycin, nuclear factor-kappa B, matrix metalloproteinase (MMP)-2, MMP-9 and caspase-3, caspase-8, and caspase-9. This review summarizes the mechanistic insights of antineoplastic action of deguelin to gain a clear understanding of its therapeutic effects in cancer. The anticancer potential of deguelin with respect to its efficacy in targeting tumorigenesis via nanotechnological approaches is also investigated. The initial scientific findings have presented deguelin as a promising antitumorigenic agent which can be used for monotherapy as well as synergistically to augment efficacy of chemotherapeutic treatment regimes.