Apoptosis of enterocytes and nitration of junctional complex proteins promote alcohol-induced gut leakiness and liver injury

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作   者：

Cho, Young-Eun;  Yu, Li-Rong;  Abdelmegeed, Mohamed A.;  Yoo, Seong-Ho;  Song, Byoung-Joon; 

作者机构：

Dept Forens Med;  Seoul Natl Univ;  South Korea;  AR;  Div Syst Biol;  Lab Membrane Biochem;  Coll Med;  Seoul;  MD 20892 USA;  NIAAA;  US FDA;  Bethesda;  Jefferson;  Sect Mol Pharmacol & Toxicol;  Biomarkers & Alternat Models Branch;  Natl Ctr Toxicol Res; 

关键词：

Ubiquitin-dependent proteolysis;  Nitroxidative stress;  Ethanol;  Protein nitration;  Cytochrome P450-2E1 (CYP2E1);  Gut leakiness;  Tight and adherens junction proteins;  Apoptosis; 

期刊名称：

Journal of Hepatology: The Journal of the European Association for the Study of the Liver

i s s n：

0168-8278

年卷期：

2018 年 69 卷 1 期

页   码：

142-153

页   码：

摘   要：

Background & Aims: Binge alcohol exposure causes gut leakiness, contributing to increased endotoxemia and inflammatory liver injury, although the molecular mechanisms are still elusive. This study was aimed at investigating the roles of apoptosis of enterocytes and nitration followed by degradation of intestinal tight junction (TJ) and adherens junction (AJ) proteins in binge alcohol-induced gut leakiness.