In vitro and in vivo safety studies of cinnamon extract (Cinnamomum cassia) on general and genetic toxicology

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作   者：

Yun, Jun-Won;  You, Ji-Ran;  Kim, Yun-Soon;  Kim, Seung-Hyun;  Cho, Eun-Young;  Yoon, Jung-Hee;  Kwon, Euna;  Jang, Ja-June;  Park, Jin-Sung;  Kim, Hyoung-Chin;  Che, Jeong-Hwan;  Kang, Byeong-Cheol; 

作者机构：

Bucheon;  Korea Res Inst Biosci & Biotechnol;  Australia;  Seoul Natl Univ;  Royal North Shore Hosp;  NSW;  Dept Neurogenet;  Seoul Natl Univ Hosp;  Coll Med;  Seoul;  Lab Anim Resource Ctr;  Dept Expt Anim Res;  Biomed Ctr Anim Resource & Dev;  Seoul 110799;  South Korea;  St Leonards;  Dept Pathol;  Dept Biotechnol;  103 Daehak Ro;  Kolling Inst;  Biomed Res Inst;  Catholic Univ Korea;  Cheongju; 

关键词：

Cinnamomum cassia;  Subchronic;  Toxicity;  Genotoxicity;  Cinnamon; 

期刊名称：

Regulatory Toxicology and Pharmacology: RTP

i s s n：

0273-2300

年卷期：

2018 年 95 卷

页   码：

115-123

页   码：

摘   要：

Cinnamomum cassia has been widely used as a natural product to treat diseases in Asia due to its diverse pharmacological functions including anti-inflammatory, anti-oxidant, anti-microbial, anti-diabetic, and antitumor effects. Despite its ethnomedicinal benefits, little information regarding its toxicity is currently available. The aim of this study was to evaluate its potential long-term toxicity and genotoxicity in compliance with test guidelines of the Organization for Economic Cooperation and Development. A 13-week repeat-dose oral toxicity study revealed that body weights of rats were normal after receiving cinnamon extract at up to 2000 mg/kg. High-dose intake of cinnamon extract (2000 mg/kg) showed potential nephrotoxicity and hepatotoxicity to both males and females as evidenced by obvious increases of kidney/liver weight along with a small but statistically elevation of total cholesterol level. Overall findings from genetic toxicity testing battery including Ames test, in vitro mammalian cell micronucleus assay, and in vivo bone marrow micronucleus assay indicated that cinnamon extract was not mutagenic or clastogenic. In conclusion, cinnamon extract may possess potential nephrotoxicity and hepatotoxicity at dose higher than its recommended daily safe dose. Further study is needed to clarify the mechanism involved in its induction of liver and kidney injury.