Adaptation of pharmaceutical excipients to FDM 3D printing for the fabrication of patient-tailored immediate release tablets

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作   者：

Sadia, Muzna;  Sosnicka, Agata;  Arafat, Basel;  Isreb, Abdullah;  Ahmed, Waqar;  Kelarakis, Antonios;  Alhnan, Mohamed A.; 

作者机构：

Preston;  England;  Sch Phys Sci & Comp;  Sch Med;  Sch Pharm & Biomed Sci;  Preston PR1 2HE;  MB025 Maudland Bldg;  Univ Cent Lancashire;  Lancs; 

关键词：

Three dimensional printing;  Patient-specific;  Personalized;  Fused filament fabrication; 

期刊名称：

International Journal of Pharmaceutics

i s s n：

0378-5173

年卷期：

2016 年 513 卷 1/2 期

页   码：

659-668

页   码：

摘   要：

This work aims to employ fused deposition modelling 3D printing to fabricate immediate release pharmaceutical tablets with several model drugs. It investigates the addition of non-melting filler to methacrylic matrix to facilitate FDM 3D printing and explore the impact of (i) the nature of filler, (ii) compatibility with the gears of the 3D printer and iii) polymer: filler ratio on the 3D printing process. Amongst the investigated fillers in this work, directly compressible lactose, spray-dried lactose and microcrystalline cellulose showed a level of degradation at 135 degrees C whilst talc and TCP allowed consistent flow of the filament and a successful 3D printing of the tablet. A specially developed universal filament based on pharmaceutically approved methacrylic polymer (Eudragit EPO) and thermally stable filler, TCP (tribasic calcium phosphate) was optimised. Four model drugs with different physicochemical properties were included into ready-to-use mechanically stable tablets with immediate release properties. Following the two thermal processes (hot melt extrusion (HME) and fused deposition modelling (FDM) 3D printing), drug contents were 94.22%, 88.53%, 96.51% and 93.04% for 5-ASA, captopril, theophylline and prednisolone respectively. XRPD indicated that a fraction of 5-ASA, theophylline and prednisolone remained crystalline whilst captopril was in amorphous form. By combining the advantages of thermally stable pharmaceutically approved polymers and fillers, this unique approach provides a low cost production method for on demand manufacturing of individualised dosage forms. (C) 2016 Elsevier B.V. All rights reserved.