Estimating lung ventilation directly from 4D CT Hounsfield unit values

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作   者：

Kipritidis, John;  Hofman, Michael S.;  Siva, Shankar;  Callahan, Jason;  Le Roux, Pierre-Yves;  Woodruff, Henry C.;  Counter, William B.;  Keall, Paul J.; 

作者机构：

Radiat Phys Lab;  Vic 3002;  Sydney Med Sch;  Australia;  NSW 2006;  Univ Sydney;  Sydney;  Peter MacCallum Canc Ctr;  Melbourne;  Div Radiat Oncol & Canc Imaging; 

关键词：

lung cancer;  CT ventilation imaging;  4DCT;  deformable image registration;  PET ventilation; 

期刊名称：

Medical Physics

i s s n：

0094-2405

年卷期：

2016 年 43 卷 1 期

页   码：

33-43

页   码：

摘   要：

Purpose: Computed tomography ventilation imaging (CTVI) aims to visualize air-volume changes in the lung by quantifying respiratory motion in 4DCT using deformable image registration (DIR). A problem is that DIR-based CTVI is sensitive both to 4DCT image artifacts and DIR parameters, hindering clinical validation of the technique. To address this, the authors present a streamlined CTVI approach that estimates blood-gas exchange in terms of time-averaged 4DCT Hounsfield unit (HU) values without relying on DIR. The purpose of this study is to quantify the accuracy of the HU-based CTVI method using high-resolution Ga-68 positron emission tomography ("Galligas PET") scans in lung cancer patients.