Ammonium and Guanidinium Dendron-Carbon Nanotubes by Amidation and Click Chemistry and their Use for siRNA Delivery

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作   者：

Alessia Battigelli;  Julie Tzu-Wen Wang;  Julie Russier;  Tatiana Da Ros;  Kostas Kostarelos;  Khuloud T. Al-Jamal;  Maurizio Prato;  Alberto Bianco; 

作者机构：

Institut de Biologie Moléculaire et Cellulaire Laboratoire d'lmmunopathologie et Chimie Thérapeutique 67000 Strasbourg;  Drug Delivery Group;  CNRS;  Dipartimento di Scienze Chimiche e Farmaceutiche Università di Trieste 34127;  France;  UK;  Italy;  Trieste;  Institute of Pharmaceutical Science King's College London London SE19NH;  Nanomedicine Laboratory UCL School of Pharmacy University College London London WCiN 1AX; 

关键词：

Nanotubes;  dendrimeric;  MWCNT; 

期刊名称：

Small

i s s n：

1613-6810

年卷期：

2013 年 9 卷 21 期

页   码：

3610-3619

页   码：

摘   要：

A series of multi-walled carbon nanotube (MWCNT) conjugates is described, functionalized with different dendrons bearing positive charges at their termini (i.e. ammonium or guanidinium groups). The dendrimeric units are anchored to the nanotube scaffolds using two orthogonal synthetic approaches, amidation and click reactions. The final nanohybrids are characterized by complementary analytical techniques, while their ability to interact with siRNA is investigated by means of agarose gel electrophoresis. The demonstration of the cell uptake capacity, the low cytotoxicity, and the ability of these cationic conjugates to silence cytotoxic genes suggests them to be promising carriers for genetic material.