Emerging pharmacological strategies in the fight against cocaine addiction.

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作   者：

Sofuoglu M;  Kosten TR; 

作者机构：

West Haven;  Department of Psychiatry;  CT 06516;  Yale University;  VA Connecticut Healthcare System;  USA. Mehmet.Sofuoglu@yale.edu;  School of Medicine; 

关键词：

Fighting;  NOS;  Addiction;  Cocaine;  可卡因;  临床试验;  Clinical Trials; 

期刊名称：

Expert opinion on emerging drugs

i s s n：

1472-8214

年卷期：

2006 年 11 卷 1 期

页   码：

91-98

页   码：

摘   要：

Cocaine addiction continues to be an important public health problem worldwide. At present, there are no proven pharmacotherapies for cocaine addiction. The studies reviewed here revealed a number of emerging targets for cocaine pharmacotherapy. First, disulfiram, a medication with dopaminergic effects, reduced cocaine use in a number of clinical trials. Second, GABA medications, tiagabine and topiramate, were found promising in clinical trials. Third, a beta-adrenergic blocker, propranolol, may be effective especially among cocaine-addicted individuals with high withdrawal severity. Fourth, treatment with a stimulant medication, modafinil, has reduced cocaine use. Last, a cocaine vaccine that slows entry of cocaine into the brain holds promise. These promising findings need to be further tested in controlled clinical trials.