Straightforward hetero Diels-Alder reactions of nitroso dienophiles by microreactor technology

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作   者：

Jean-Christophe M. R. Monbaliu;  Ana Cukalovic;  Jacqueline Marchand-Brynaert; 

作者机构：

Faculty of Bioscience Engineering;  Place Louis Pasteur !;  Coupure links 653;  B-9000 Gent;  B-1348 Louvain-la-Neuve;  IMCN;  SynBioC Research Group;  Universite catholique de Louvain;  Ghent University;  Department of Sustainable Organic Chemistry and Technology;  Institute of Condensed Matter and Nanosciences;  Batiment Lavoisier;  Belgium; 

关键词：

Hetero Diels-Alder reaction;  Flow conditions;  Nitroso dienophiles;  Microreactor; 

期刊名称：

Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry

i s s n：

0040-4039

年卷期：

2010 年 51 卷 44 期

页   码：

5830-5833

页   码：

摘   要：

The hetero Diels-Alder reactions of 2-nitrosotoluene and some representative acylnitrosodienophiles with a selected set of 1,3-dienes were studied under microflow conditions. The main assets of the technology, that is, an accurate control of the reaction parameters and continuous operating, led to an increased efficiency of this reaction.