Novel 4- and 7-Sulfonylated 2-Substituted Benzoxazoles

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作   者：

Frederic Bruyneel;  Jacqueline Marchand-Brynaert; 

作者机构：

Organic and Medicinal Chemistry (CHOM);  Université catholique de Louvain;  Place Louis Pasteur 1;  Institute of Condensed Matter and Nanosciences (IMCN);  1348 Louvain-la-Neuve;  Batiment Lavoisier;  Belgium; 

关键词：

heterocycles;  acetals;  condensation;  cyclization;  sub-stituents effects; 

期刊名称：

Synlett

i s s n：

0936-5214

年卷期：

2010 年 13 期

页   码：

1974-1978

页   码：

摘   要：

The efficient synthesis of sulfonylated benzoxazoles at positions C4 or C7 is reported. The condensation reactions involve original anilide acetal reagents which, upon acid catalysis, allow an easy cyclization reaction with the sulfonylated o-aminophenol part-ners. This method circumvents the classical use of orthoesters which drawback is the limited access to aromatic reagents.