An efficient synthesis of O,O-di propyl (E)-2-[1-methyl 2-oxopropylidene]phosphorohydrazidothiolate (E) oxime and its analogues: A potential marine toxin

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作   者：

Gupta AK;  Dubey DK;  Parashar BD;  Kaushik MP; 

作者机构：

Def Res & Dev Estab;  Proc Technol Dev Div;  India;  Madhya Pradesh;  Gwalior 474002; 

关键词：

phosphoric acid hydrazides;  OXIDATION;  RED-TIDE DINOFLAGELLATE;  ACIDS;  IMINES;  ptychodiscus brevis;  thiophosphoric acid hydrazide;  GYMNODINIUM-BREVE;  fish toxin; 

期刊名称：

Phosphorus, Sulfur, and Silicon and the Related Elements

i s s n：

1042-6507

年卷期：

2008 年 183 卷 8 期

页   码：

1892-1910

页   码：

摘   要：

An efficient method for the synthesis of Ptychodiscus brevis toxin O,O- di n-propyl (E)-2-[1-methyl 2-oxopropylidene]phosphorohydrazidothiolate (E) oxime (TG-1) and its analogues has been developed using thermally stable and recyclable silica gel and Na2SO4 as a condensing agent and water scavenger, respectively. The compounds were evaluated against fish Rasbora daniconius by determining the LC50 and LC90 values. The results of biological evaluation showed that these compounds have high degree of toxicity.