Vaccine adjuvant: it makes the difference

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作   者：

Lima KM;  dos Santos SA;  Rodrigues JM;  Silva C; 

作者机构：

BR-14049900 Sao Paulo;  Lima KM;  Sch Med Ribeirao Preto;  Inst Milenio Rede TB;  Univ Sao Paulo;  Ave Bandeirantes 3900;  Brazil;  Ctr;  Tuberculosis Res; 

关键词：

Mycobacterial hsp65;  T-cells;  Tuberculosis;  Dendritic cells;  Delivery-systems;  Modulation;  Adjuvant;  Vaccine;  Mice;  Protection; 

期刊名称：

Vaccine

i s s n：

0264-410X

年卷期：

2004 年 22 卷 19 期

页   码：

2374-2379

页   码：

摘   要：

The use of protein or DNA in vaccination process rather than living or attenuated microorganism, aims at the increase of the vaccines safety. However, in these cases, the use of adjuvant is frequently required to improve their immunogenicity. In this study, we show the importance of the adjuvant in a vaccine formulation. Vaccines for tuberculosis provide an instructive example, based on the mycobacterial 65 kDa heat shock protein (hsp65). The same antigen can elicit completely different patterns of immune response depending on how it is administered. Thus, the same antigen might or not protect mice from challenge with Mycobacterium tuberculosis, depending on the formulation. These data suggest that, despite the name, the adjuvant plays a fundamental role on the vaccination process.