Two new sesquiterpenol caffeates from Bauhinia brychycarpa Wall. ex Benth. and their α-glucosidase inhibitory activity

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作   者：

Zhang, Xingping;  Ma, Wenjie;  Huang, Kepu;  Gao, Congxi;  Jiang, Xiaoxue;  Li, Mingming;  Wang, Kou; 

作者机构：

Yunnan Univ Chinese Med;  Kunming Med Univ;  Yunnan Coll Modern Biomed Ind; 

关键词：

DP4+;  Bauhinia brychycarpa Wall. ex Benth.;  ECD calculation;  alpha-Glucosidase inhibitory activity;  Sesquiterpenol caffeate; 

期刊名称：

Fitoterapia

i s s n：

0367-326X

年卷期：

2025 年 180 卷

页   码：

摘   要：

Two new sesquiterpenol caffeates, bausesquitate A (1) and bausesquitate B (2), were isolated from the stems and leaves of Bauhinia brychycarpa. Structures of two compounds were confirmed by UV, IR, HR-ESI-MS, 1D and 2D NMR, ECD spectra and DP4+ probability analysis. In vitro, compounds 1 and 2 showed better inhibitory effect on alpha-glucosidase than acarbose (IC50 = 280.50 +/- 6.27 mu M) with the IC50 values of 1.81 +/- 0.12 mu M and 3.79 +/- 0.27 mu M. Additionally, molecular docking and molecular dynamics simulation were performed to analyze the potential binding sites.