Cellulitis at injection site: Case definition and guidelines for collection, analysis, and presentation of immunization safety data

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作   者：

Scott Halperin;  Katrin S. Kohl;  Jane Gidudu;  Leslie Ball;  Sandra Jo Hammer;  Paul Heath;  Renald Hennig;  Jerry Labadie;  Edward Rothstein;  Anne Schuind;  Frederick Varricchio;  Wikke Walop; 

作者机构：

Dalhousie University;  Halifax;  Nova Scotia;  Canada; 

关键词：

Immunization;  Case definition;  Adverse event;  Cellulitis;  Guidelines; 

期刊名称：

Vaccine

i s s n：

0264-410X

年卷期：

2007 年 25 卷 31 期

页   码：

5803-5820

页   码：

摘   要：

Cellulitis is an inflammatory condition of the skin [1], and is a rare adverse event following immunization. Although cellulitis resulting from chemical trauma to the skin can occur, most cellulitis after immunization is the result of bacterial infection by indigenous flora colonizing the skin and appendages, or by a wide variety of exogenous bacteria [2-4]. Because cellulitis after immunization can occur due to unsafe injection techniques or vaccine vial handling or storage, and because it can clinically be confused with other skin reactions to immunization, it is important to develop standardized diagnostic criteria to guide the appropriate public health intervention, and to improve global comparability of vaccine safety data on cellulitis.