Mechanistic investigation of repurposed photoenzymes with new-to-nature reactivity

• 全文链接

对具有天然新反应性的再利用光酶的机制研究

关键词：

来源：

Current Opinion in Green and Sustainable Chemistry

全文链接：

//agri.nais.net.cn/topic/downloadFile/491cb326-f5f1-4dc8-a5cd-12e506d30360

来源地址：

https://doi.org/10.1016/j.cogsc.2025.101009

资源所属：

饲料用酶工程

类型：

学术文献

语种：

英语

原文发布日期：

2025-02-27

摘要：

Biocatalysis is widely renowned for its remarkable efficiency, selectivity, and known for operating under mild conditions. While most enzymatic reactions progress without light irradiation, recent studies have identified light as a crucial factor in the activation of certain naturally occurring enzymes. These findings have spurred the rapid advancement of photoenzymatic catalysis in the past few years, where enzymes are not typically known for light activation perform excited-state chemistry with or without the presence of external photocatalysts to facilitate new-to-nature transformations that are challenging for traditional chemical synthesis. In this review, we summarize the experimental and computational methods used to investigate the catalytic mechanisms of repurposed photoenzymes with new-to-nature reactivity and discuss how these insights can inform the design of new photoenzymatic catalytic systems.