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Development of targeted therapies for peroxisome biogenesis disorders
- 负责人：
- 关键词：
- Molecular Biology peroxisome biogenesis disorders peroxins PEX1 high-content screening small molecules induced pluripotent stem cells HepG2 cells Pex1-p.G844D mouse
- DOI：
- doi:10.25549/usctheses-c40-298640
- 摘要：
- Peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous rare metabolic diseases caused by defects in peroxins, proteins
Data from: RRapid global spread of wRi-like Wolbachia across multiple Drosophila
- 负责人：
- DOI：
- doi:10.5061/dryad.4kt079g
- 摘要：
- insect pests and vector-borne diseases with Wolbachia transinfections.
Data from: Assessing gene-environment interactions for common and rare variants with binary traits using gene-trait similarity regression
- 负责人：
- DOI：
- doi:10.5061/dryad.742gv
- 摘要：
- o the biological mechanisms of complex diseases, help to identify high-risk subgroups in the population, and uncover hidden heritability. However, significant GxE intera
Data from: Joint prediction of multiple quantitative traits using a Bayesian multivariate antedependence model
- 负责人：
- DOI：
- doi:10.5061/dryad.dd60v
- 摘要：
- hough genome-wide association studies (GWAS) for complex traits have discovered a large number of trait- and disease-associated variants, phenotype
Data from: Susceptibility to type 2 diabetes may be modulated by haplotypes in G6PC2, a target of positive selection
- 负责人：
- 关键词：
- DOI：
- doi:10.5061/dryad.pk50t
- 摘要：
- , and G6PC3). Mutations in G6PC and G6PC3 are responsible for human mendelian diseases, whereas variants in G6PC2 are associated with fasting glucose (FG
Data from: Experimental investigation of alternative transmission functions: quantitative evidence for the importance of non-linear
- 负责人：
- Orlofske, Sarah
- DOI：
- doi:10.5061/dryad.1pk42
- 摘要：
- 1. Understanding pathogen transmission is crucial for predicting and managing disease. Nonetheless, experimental comparisons of alternative
Data from: Climatic variation modulates the indirect effects of large herbivores on small-mammal habitat use
- 负责人：
- Long, Ryan
- 关键词：
- Context-dependence Contingency Herbivory Ungulates and elephants Habitat use Climate change African savannas Ecosystem engineering Trait-mediated indirect interactions (TMII) Zoonotic disease risk
- DOI：
- doi:10.5061/dryad.p112b
- 摘要：
- infall in East Africa (as predicted in many recent climate-model simulations) may relax constraints on small-mammal distribution where LMH are rare or absent, wherea
Data from: Self-fertilization and herbivory in a rare alpine plant in California, Claytonia megarhiza (Montiaceae)
- 负责人：
- Grossenbacher, Dena
- 关键词：
- ant breeding system mating system outcrossing pollination reproductive assurance selfing geographic range edge
- DOI：
- doi:10.5061/dryad.tr20q
- 摘要：
- cts alternative strategies for sexual reproduction in plants: compensatory measures such as larger floral displays and greater floral longevity to attract scarce pollinators
Data from: Allee effects may slow the spread of parasites in a coastal marine ecosystem
- 负责人：
- DOI：
- doi:10.5061/dryad.34g16868
- 摘要：
- on parasites have rarely been considered in the analogous process of infectious disease establishment and spread. We studied the colonization of uninfected wild
Data from: Evidence that hepatitis C virus genome partly controls infection outcome
- 负责人：
- DOI：
- doi:10.5061/dryad.3978f
- 摘要：
- cases including viraemic subjects who ultimately clear the virus, thus providing us with a unique collection of sequences from clearing infections
