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Data from: Single cell RNA-seq analysis reveals that prenatal arsenic exposure results in long-term, adverse effects on immune gene expression in response to Influenza A infection
- 负责人：
- DOI：
- doi:10.5061/dryad.vt4b8gtp6
- 摘要：
- ater lung damage and inflammation in arsenic exposed mice versus control mice. Single-cell RNA sequencing analysis of immune cells harvested from IAV infected lungs
Data from: Numerical simulations of targeted delivery of magnetic drug aerosols in the human upper and central respiratory system: a validation study
- 负责人：
- DOI：
- doi:10.5061/dryad.0jt43
- 摘要：
- In the present study, we investigate the concept of the targeted delivery of pharmaceutical drug aerosols in an anatomically realistic geometry of the human upper and central respiratory system. The geometry considered extends from the mouth inlet to the 8th generation of the bronchial bifurcations and is identical to the phantom model used in the experimental studies of [Banko {em et al.} (2015), Exp. Fluids, {bf 56} (117):1-12]. In our computer simulations, we combine the transitional Reynolds-Averaged Navier-Stokes (RANS) and the wall-resolved Large Eddy Simulation (LES) methods for the air phase with the Lagrangian approach for the particulate (aerosol) phase. We validated simulations against recently obtained magnetic resonance velocimetry (MRV) measurements of [Banko {em et al.} (2015), Exp. Fluids, {bf 56} (117):1-12] that provide full a 3D mean velocity field for steady inspiratory conditions. Both approaches produced good agreement with experiments, and the transitional RANS approach is selected for the multi-phase simulations of aerosols transport, because of significantly lower computational costs. The local and total deposition efficiency are calculated for different classes of pharmaceutical particles (in the $0.1mu$m$le d_{rm p} le 10mu$m range) without and with a paramagnetic core (the shell-core particles). For the latter, an external magnetic field is imposed. The source of the imposed magnetic field was placed in the proximity of the first bronchial bifurcation. We demonstrated that both total- and local-depositions of aerosols at targeted locations can be significantly increased by an applied magnetization force. This finding confirms the possible potential for further advancement of the magnetic drug targeting (MDT) technique for more efficient treatments for respiratory diseases.
Data from: Laboratory contamination in airway microbiome studies
- 负责人：
- DOI：
- doi:10.5061/dryad.1v92t8b
- 摘要：
- Background: The low bacterial load in samples acquired from the lungs, have made studies on the airway microbiome vulnerable to contamination from
Data from: Regulatory CD4+CD25+ T cells dampen inflammatory disease in murine mycoplasma pneumonia and promote IL-17 AND IFN-? responses
- 负责人：
- DOI：
- doi:10.5061/dryad.h82r4
- 摘要：
- into lungs also occurred after CD25+ cell depletion. CD4+CD25+ regulatory T cells promoted IFN-? and IL-17 mycoplasma-specific CD4+ T cell
Data from: Parallel telomere shortening in multiple body tissues owing to malaria infection
- 负责人：
- 关键词：
- malaria;systemic stress;cost of infection;Aging;Plasmodium ashfordi;Spinus spinus;telomere length
- DOI：
- doi:10.5061/dryad.3477v
- 摘要：
- investigated (liver, lungs, spleen, heart, kidney, and brain) in infected birds compared with controls at 105 DPI. To the best of our knowledge, this is the fir
Data from: Adult MTM1-related myopathy carriers: classification based on deep phenotyping
- 负责人：
- DOI：
- doi:10.5061/dryad.116n37m
- 摘要：
- , pulmonary function tests (PFTs) and physical therapy assessments including the Motor Function Measure 32 (MFM-32) scale were performed. Results Phenotypic categories wer
Data from: Identification of any structure-specific hepatotoxic potential of different pyrrolizidine alkaloids using Random Forest and artificial Neural Network
- 负责人：
- 关键词：
- DOI：
- doi:10.5061/dryad.qn7d3
- 摘要：
- structural subcategories. The main target organs for PA metabolism and toxicity are liver and lungs. Additionally, PAs are potentially genotoxic, carcinogenic
Data from: Efficacy and safety of four weeks’ treatment with combined fluticasone furoate/vilanterol in a single inhaler given once daily in COPD: a placebo-controlled randomised trial
- 负责人：
- DOI：
- doi:10.5061/dryad.7p1r30q5
- 摘要：
- in development for chronic obstructive pulmonary disease (COPD) and asthma. TRIAL DESIGN: A multicentre, randomised, double-blind, parallel-gr
Therapeutic potential of rhesus theta (θ) defensin-1 in cystic fibrosis airway infection and inflammation
- 负责人：
- 关键词：
- Clinical and Experimental Therapeutics cystic fibrosis infection inflammation preclinical drug development
- DOI：
- doi:10.25549/usctheses-c40-309144
- 摘要：
- and anti-inflammatory activity in the lungs of chronically infected CF mice receiving aerosolized RTD-1. Furthermore, the safety of aerosolized RTD-1 was supported by airway
Proinsulin-transferrin fusion protein as a liver targeting insulin therapeutic in Type 1 diabetes treatment
- 负责人：
- 关键词：
- Pharmaceutical Sciences proinsulin-transferrin fusion protein liver targeting diabetes long-acting insulin therapeutic
- DOI：
- doi:10.25549/usctheses-c40-250950
- 摘要：
- Long-acting insulin (INS) analogs have been used in the treatment of INS-deficient diabetes patients to meet INS needs between meal times and duri
