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Data from: Corticosterone: effects on feather quality and deposition into feathers
- 负责人：
- DOI：
- doi:10.5061/dryad.7tm53
- 摘要：
- ) and double-checked the results with ultra-high performance liquid chromatography-tandem mass spectrometry (LCMS) (CORTMS). 4. Administered CORT affec
Data from: Feather steroid hormone concentrations in relation to age, sex, and moulting time in a long distance migratory passerine
- 负责人：
- DOI：
- doi:10.5061/dryad.v4bf803
- 摘要：
- of hormones before LC-MS/MS analysis. Unlike previously used methods (RIA, EIA), our analytical procedure allows simultaneous analysis of both hormones from sma
Data from: Solubilisation of phosphate and micronutrients by Trichoderma harzianum and its relationship with the promotion of tomato plant growth
- 负责人：
- 关键词：
- DOI：
- doi:10.5061/dryad.p460c
- 摘要：
- e detected by HPLC and LC/MS in two Trichoderma cultures. Additionally, we inoculated tomato seedlings with SQR-T037 using a hydroponic system with specific
Data from: Fossilization of melanosomes via sulfurization
- 负责人：
- Maria McNamara
- DOI：
- doi:10.5061/dryad.540q6
- 摘要：
- of original colour in fossils based on potential sulfur-rich phaeomelanosomes. Here we use pyrolysis gas chromatography mass spectrometry (Py-GCMS
Data from: Tumor suppressor RARRES1- a novel regulator of fatty acid metabolism in epithelial cells
- 负责人：
- DOI：
- doi:10.5061/dryad.6t1m4k4
- 摘要：
- h as hepatic steatosis, hyperinsulinemia and obesity. Here we report a novel function of RARRES1 in metabolic reprogramming of epithelial cells. Using non-targeted LC-MS
Data from: Discovery of metabolic biomarkers for Duchenne Muscular Dystrophy within a natural history study
- 负责人：
- DOI：
- doi:10.5061/dryad.qg6q2
- 摘要：
- coupled to mass spectrometry (LC-MS) for discovery of novel circulating serum metabolites associated with DMD. Fourteen metabolites were found signific
Data from: Vitamin D receptor gene expression and function in a South African population: ethnicity, vitamin D and FokI
- 负责人：
- DOI：
- doi:10.5061/dryad.12dp5
- 摘要：
- in the study (African, n = 40 and White, n = 20). Plasma 25(OH)D3 levels were quantified by LC-MS and monocytes cultured, with or without 1,25(OH)2D3
Data from: Extraction and separation of active ingredients in Schisandra chinensis (Turcz.) Baill and the study of their antifungal effects
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- 关键词：
- DOI：
- doi:10.5061/dryad.21533
- 摘要：
- a High-Performance Liquid Chromatography-ElectroSpray Ionization-Mass Spectrometry (HPLC-ESI-MS) analyses of the active fractions. Moreover, the results from biological test
Data from: Of 11 candidate steroids, corticosterone concentration standardized for mass is the most reliable steroid-biomarker of nutritional stress across different feather types
- 负责人：
- DOI：
- doi:10.5061/dryad.83533nh
- 摘要：
- 1. Measuring corticosterone in feathers has become an informative tool in avian ecology, enabling researchers to investigate carry-over effects and responses to environmental variability. Few studies have, however, explored whether corticosterone is the only hormone expressed in feathers, and is the most indicative of environmental stress. Essential questions remain as to how to compare hormone concentrations across different types of feathers and whether preening adds steroids, applied after feather growth. 2. We used liquid chromatography coupled to tandem mass spectrometry to quantify a suite of 11 steroid hormones in back, breast, tail, and primary feathers naturally grown at overlapping time intervals by rhinoceros auklet Cerorhinca monocerata captive-reared fledglings and wild-caught juveniles. The captive-reared birds were raised on either a restricted or control diet. Measured steroids included intermediates in the adrenal steroidogenesis pathway to glucocorticoids and the sex steroids pathway to androgens and estrogens. 3. Corticosterone was detected in the majority of feathers of each type. We also detected cortisone in back feathers, androstenedione in breast feathers, and testosterone in primary feathers. Captive fledglings raised on a restricted diet had higher concentrations of corticosterone in all four feather types than captive fledglings raised on a control diet. Corticosterone concentrations were reliably repeatable across feather types when standardized for feather mass, but not for feather length. Of the seven hormones looked for in uropygial gland secretions, only corticosterone was detected in one out of 23 samples. 4. We conclude that corticosterone is the best feather-steroid biomarker for detection of developmental nutritional stress, as it was the only hormone to manifest a signal of nutritional stress, and that exposure to stress can be compared among different feather types when corticosterone concentrations are standardized by feather mass.
Data from: Dietary macronutrients modulate the fatty acyl composition of rat liver mitochondrial cardiolipins
- 负责人：
- 关键词：
- LC-MS mitochondria cardiolipin ubiquinones saturated fatty acids trans fatty acids monounsaturated fatty acids polyunsaturated fatty acids glycemic index lipidomics
- DOI：
- doi:10.5061/dryad.1t93v
- 摘要：
- The interaction of dietary fats and carbohydrates on liver mitochondria were examined in male FBNF1 rats fed 20 different low-fat, isocaloric diets. Animal growth rates and mitochondrial respiratory parameters were essentially unaffected, but mass spectrometry-based, mitochondrial lipidomics profiling revealed increased levels of cardiolipins (CLs), a family of phospholipids essential for mitochondrial structure and function, in rats fed saturated or trans fat-based diets with a high glycemic index. These mitochondria showed elevated monolysocardiolipins (a CL precursor/product of CL degradation), elevated ratio of trans PC (18:1/18:1) to cis PC (18:1/18:1) (a marker of thiyl radical stress), and decreased ubiquinone Q9 -- the latter two of which imply a low-grade mitochondrial redox abnormality. Extended analysis demonstrated: (i) dietary fats and, to a lesser extent, carbohydrates induce changes in the relative abundance of specific CL species; (ii) Fatty acid (FA) incorporation into mature CLs undergoes both positive (>400-fold) and negative (2.5-fold) regulation; and, (iii) dietary lipid abundance and incorporation of FAs into both the CL pool and specific mature tetra-acyl CLs are inversely related, suggesting previously unobserved compensatory regulation. This study reveals previously unobserved complexity/regulation of the central lipid in mitochondrial metabolism.
