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Wildlife sequences of islet amyloid polypeptide (IAPP) identify critical species variants for fibrillization
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- 关键词：
- Information and Computing Sciences Biological Sciences Ecology Chemistry Earth and Environmental Sciences Molecular Biology Biochemistry Biophysics
- DOI：
- doi:10.6084/m9.figshare.1568456.v1
- 摘要：
- Amyloid can be detected in the islets of Langerhans in a majority of type 2 diabetic patients. These deposits have been associated with β-cell death
Data from: PPAR? promotes diabetes-associated centrosome amplification via increasing the expression of SKA1 directly at the transcriptional level
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- DOI：
- doi:10.5061/dryad.hg225q3
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- We have published recently that type 2 diabetes can induce cell centrosome amplification, due to the action of high glucose, palmitic acid
Data from: Task shifting interventions for cardiovascular risk reduction in low-and middle-income countries: a syste
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- DOI：
- doi:10.5061/dryad.565kh
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- in the management of CV risk factors and diseases (hypertension, diabetes, hyperlipidaemia, stroke, coronary artery disease or heart failure), as well as RCTs tha
Data from: Intestinal Ralstonia pickettii augments glucose intolerance in obesity
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- DOI：
- doi:10.5061/dryad.q5s51
- 摘要：
- ity and type 2 diabetes mellitus (T2DM). Low grade inflammation, potentially initiated by the intestinal microbiota, has been suggested to be a driving force in the development of
RAS-modification as a novel therapy for pulmonary indications in T2D
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- 关键词：
- Clinical and Experimental Therapeutics T2DM angiotensin(1-7) immune function lung fibrosis pulmonary indications
- DOI：
- doi:10.25549/usctheses-c40-350071
- 摘要：
- Introduction. Patients with type 2 diabetes mellitus (T2DM) are not only prone to lung infections, the severity of the infection is also li
Data from: Childhood adiposity and type 1 diabetes: a Mendelian randomization study
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- DOI：
- doi:10.5061/dryad.ns8q3
- 摘要：
- BACKGROUND: The incidence of type 1 diabetes (T1D) is increasing globally. One hypothesis is that increasing childhood obesity rates may explain par
Data from: The neuropathic diabetic foot ulcer microbiome is associated with clinical factors.
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- DOI：
- doi:10.5061/dryad.042vn
- 摘要：
- Nonhealing diabetic foot ulcers (DFUs) are a common and costly complication of diabetes. Microbial burden, or "bioburden," is believed to underlie
Data from: Longitudinal associations between diurnal cortisol variation and later life cognitive impairment
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- DOI：
- doi:10.5061/dryad.vb3g6p1
- 摘要：
- . Models were adjusted for age, sex, diagnoses of hypertension, diabetes, BMI, educational attainment and interval between HPAA and cognitive asses
Data from: Tang-Nai-Kang alleviates pre-diabetes and metabolic disorders by inducing a gene expression switch toward fatty acid oxidation in SHR.Cg
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- DOI：
- doi:10.5061/dryad.3hj96
- 摘要：
- Increased energy intake and reduced physical activity can lead to obesity, diabetes and metabolic syndrome. Transcriptional modulation
Data from: The E3 ubiquitin ligase MARCH1 regulates glucose-tolerance and lipid storage in a sex-specific manner
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- 关键词：
- DOI：
- doi:10.5061/dryad.r34k1
- 摘要：
- Type 2 diabetes is typified by insulin-resistance in adipose tissue, skeletal muscle, and liver, leading to chronic hyperglycemia. Addi
