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共检索到133条 ,权限内显示50条;
Data from: NF-?B oscillations translate into functionally related patterns of gene expression
- 负责人：
- DOI：
- doi:10.5061/dryad.j62n1
- 摘要：
- t transcription of NF-?B-controlled genes also oscillates, but mature transcript levels follow three distinct patterns. Two sets of transcripts accumulate fast
Data from: Cyclin dependent kinase 5 (CDK5) regulates the circadian clock
- 负责人：
- DOI：
- doi:10.5061/dryad.4067r78
- 摘要：
- Circadian oscillations emerge from transcriptional and post-translational feedback loops. An important step in generating rhythmicity
Data from: Hypothalamic transcriptomes of 99 mouse strains reveal trans eQTL hotspots, splicing QTLs and novel non-coding genes
- 负责人：
- DOI：
- doi:10.5061/dryad.vm525
- 摘要：
- valuable insight into the underlying molecular mechanisms. We used RNA-Seq to characterize hypothalamic transcriptome in 99 inbred strains of mice from
Data from: Transcriptome resources for the white-footed mouse (Peromyscus leucopus): new genomic tools for investigating ecologically divergent
- 负责人：
- DOI：
- doi:10.5061/dryad.6hc0f
- 摘要：
- e annotated from comparisons to Mus musculus (39.96% annotated) Uniprot databases. We identified 104,655 high quality single nucleotide polymorphisms (SNPs)
Data from: Sexual selection constrains the body mass of male but not female mice
- 负责人：
- DOI：
- doi:10.5061/dryad.v3p2g
- 摘要：
- this hypothesis by retrospectively assessing the influence of body mass, one metric of body size, on the fitness of 113 wild-derived house mice (Mus musculus
Data from: Experimental manipulation of population-level MHC diversity controls pathogen virulence evolution in Mus musculus
- 负责人：
- DOI：
- doi:10.5061/dryad.3h0q8
- 摘要：
- The virulence levels attained by serial passage of pathogens through similar host genotypes are much higher than observed in natural systems, however, it is unknown what keeps natural virulence levels below these empirically demonstrated maximum levels. One hypothesis suggests that host diversity impedes pathogen virulence, because adaptation to one host genotype carries tradeoffs in the ability to replicate and cause disease in other host genotypes. To test this hypothesis, with the simplest level of population diversity within the loci of the major histocompatibility complex (MHC), we serially passaged Friend Virus Complex (FVC) through two rounds, in hosts with either the same MHC genotypes (pure passage) or hosts with different MHC genotypes (alternated passage). Alternated passages showed a significant overall reduction of viral titer (31%) and virulence (54%) when compared to pure passages. Furthermore, a resistant host genotype initially dominated any effects due to MHC diversity, however, when FVC was allowed to adapt to the resistant host genotype, predicted MHC effects emerged, i.e. alternated lines show reduced virulence. These data indicate serial exposure to diverse MHC genotypes is an impediment to pathogen adaptation, suggesting genetic variation at MHC loci is important for limiting virulence in a rapidly evolving pathogen and supports negative frequency-dependent selection as a force maintaining MHC diversity in host populations.
Data from: TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal
- 负责人：
- DOI：
- doi:10.5061/dryad.62gj0
- 摘要：
- of TAFs in directing genomic occupancy of a transcriptional activator. Using liver-specific inactivation in mice, we show that the TAF4 subunit of TFIID
Data from: Effects of a titin mutation on force enhancement and force depression in mouse soleus muscles
- 负责人：
- DOI：
- doi:10.5061/dryad.3vm2818
- 摘要：
- er isovelocity stretching and shortening at three activation levels. Muscles from mdm mice (muscular dystrophy with myositis) have a predicted 83 amino acid
Data from: Rates of evolution: a quantitative synthesis
- 负责人：
- DOI：
- doi:10.5061/dryad.1tn7123
- 摘要：
- One-generation step intervals, differences, and rates; longer base intervals, differences, and rates; and overlapping net intervals, differences, and rates for selection experiments (file 1: 15,431 rates), field studies (file 2: 12,461 rates), and fossil studies (file 3: 47,854 rates).
Data from: Cyfip1 regulates presynaptic activity during development
- 负责人：
- DOI：
- doi:10.5061/dryad.nt60p
- 摘要：
- by dysregulation of the WAVE regulatory complex. Such dysregulation occurs downstream of Rac1 as acute exposure to Rac1 inhibitors rescues presynaptic responses
