Data from: Reprogramming the antigen specificity of B cells using genome-editing technologies

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关键词：

HIV broadly neutralizing antibodies;PG9;HIV vaccine;HIV bnAbs genome editing;B cells;antibody repertoire

DOI：

doi:10.5061/dryad.45j0r70

摘要：

cells allowed for Ig class switching and generated BCR variants with improved anti-HIV neutralizing activity. Thus, BCRs engineered in this way retain the gene

Data from: The Drosophila HNF4 nuclear receptor promotes glucose-stimulated insulin secretion and mitochondrial function in adults

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关键词：

Nuclear receptors;transcription;Gene Regulation;Mitochondria;Metabolism;dHNF4;drosophila melanogaster

DOI：

doi:10.5061/dryad.8h8q5

摘要：

findings establish an animal model for MODY1 and define a developmental reprogramming of metabolism to support the energetic needs of the mature animal.

Data from: Mutations in global regulators lead to metabolic selection during adaptation to complex environments

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关键词：

Escherichia coli;Experimental evolution;Citrobacter freundii;Adaptation

DOI：

doi:10.5061/dryad.3mj3m

摘要：

metabolic reprogramming can be readily achieved by mutations in the global response regulator arcA and the stress response regulator rpoS. We identified 46 unique single

Data from: Diet changes alter paternally inherited epigenetic pattern in male Wild guinea pigs

负责人：

关键词：

Cavia aperea;exposure;wild mammal species;DNA methylation;epigenetics;inheritance;Plasticity;Adaptation

DOI：

doi:10.5061/dryad.7bg3t6s

摘要：

a metabolic reprogramming (‘metabolic shift’). Epigenetic mechanisms, allowing an immediate and inherited adaptation may thus be important for the survival of species