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Data from: Quantitative trait loci from the host genetic background modulate the durability of a resistance gene: a rational basis for susta
- 负责人:
- DOI:
- doi:10.5061/dryad.s4n76
- 摘要:
- The combination of major resistance genes with quantitative resistance factors is hypothesized as a promising breeding strategy to preserve
Data from: Frequency and fitness consequences of bacteriophage ?6 host range mutations
- 负责人:
- DOI:
- doi:10.5061/dryad.5cs10
- 摘要:
- , Pseudomonas pseudoalcaligenes. In total, we found at least 17 unique suites of mutations among these 69 mutants. We assayed fitness for 13 of 17 mutant genotypes
Data from: Resource limitation prevents the emergence of drug resistance by intensifying within-host competition
- 负责人:
- DOI:
- doi:10.5061/dryad.v2q3v
- 摘要:
- -resistant mutant grows to high densities, and so sickens the patient and spreads to new hosts, is determined by the competitive interactions it has with drug
Data from: Effects of genotype on rates of substitution during experimental evolution
- 负责人:
- DOI:
- doi:10.5061/dryad.36td2
- 摘要:
- the simultaneous fixation of several mutations, consistent with theoretical models of multiple mutation dynamics. Moreover, patterns of substitution were indicative
Data from: Quantitative genetic variance in experimental fly populations evolving with or without environmental heterogeneity
- 负责人:
- DOI:
- doi:10.5061/dryad.sr3g0
- 摘要:
- environment is to the environment of past selection. Here we measure quantitative genetic variance for three traits important for fitness using replicated
Data from: Selection for novel metabolic capabilities in Salmonella enterica
- 负责人:
- 关键词:
- carbon sources;Salmonella enterica;Experimental evolution;new metabolic functions;Novel phenotypes
- DOI:
- doi:10.5061/dryad.2qh4k34
- 摘要:
- . We found mutants growing on 18 of these novel carbon sources, and identified the causal mutations that allowed growth for four of them. Mutations that relieve
Data from: No evidence for induction or selection of mutant sodium channel expression in the copepod Acartia husdsonica challenged
- 负责人:
- DOI:
- doi:10.5061/dryad.62v82
- 摘要:
- Alexandrium fundyense; (2) in the absence of induction, selection exerted by toxic A. fundyense would favor copepods that predominantly express the mutant isoform
Data from: Epistasis buffers the fitness effects of rifampicin-resistance mutations in Pseudomonas aeruginosa
- 负责人:
- DOI:
- doi:10.5061/dryad.8858
- 摘要:
- , revealing a novel mechanism for compensatory adaptation. These results suggest that antagonistic epistasis between intragenic resistance mutations ma
Data from: Epistasis between antibiotic resistance mutations and genetic background shape the fitness effect of resistance across species
- 负责人:
- DOI:
- doi:10.5061/dryad.qn370
- 摘要:
- Antibiotic resistance often evolves by mutations at conserved sites in essential genes, resulting in parallel molecular evolution between divergent
Data from: Novel conserved genotypes correspond to antibiotic resistance phenotypes of E. coli clinical isolates
- 负责人:
- DOI:
- doi:10.5061/dryad.r8q71
- 摘要:
- strategies uncover novel mechanisms. To identify genomic variations associated with antibiotic resistance, we employed a modified genome-wide association study