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Data from: miR-9a modulates maintenance and ageing of Drosophila germline stem cells by limiting N-cadherin expression
- 负责人：
- DOI：
- doi:10.5061/dryad.30cn0
- 摘要：
- Ageing is characterized by a decline in stem cell functionality leading to dampened tissue regeneration. While the expression of microRNAs across multiple species is markedly altered with age, the mechanism by which they govern stem cell-sustained tissue regeneration is unknown. We report that in the Drosophila testis, the conserved miR-9a is expressed in germline stem cells and its levels are significantly elevated during ageing. Transcriptome and functional analyses show that miR-9a directly regulates the expression of the adhesion molecule N-cadherin (N-cad). miR-9a null mutants maintain a higher number of stem cells even in the aged tissue. Remarkably, this rise fails to improve tissue regeneration and results in reduced male fertility. Similarly, overexpression of N-cad also results in elevated stem cell number and decreased regeneration. We propose that miR-9a downregulates N-cad to enable adequate detachment of stem cells toward differentiation, thus providing the necessary directionality toward terminal differentiation and spermatogenesis.
Data from: Stable, metastable and unstable cellulose solutions
- 负责人：
- DOI：
- doi:10.5061/dryad.gv3vg
- 摘要：
- ral and compare TBAH(aq) with the classical NaOH(aq) solvent.
Data from: High genetic diversity in the offshore island populations of the tephritid fruit fly Bactrocera dorsalis
- 负责人：
- DOI：
- doi:10.5061/dryad.666sn
- 摘要：
- in one clade. Another clade consisted of Shangchuan Island and Naozhou Island, and a final, separate clade contained only the Wailingding Island population
Data from: Severe childhood speech disorder: gene discovery highlights transcriptional dysregulation
- 负责人：
- DOI：
- doi:10.5061/dryad.zkh189363
- 摘要：
- %) probands, we identified highly plausible pathogenic single nucleotide (n=10, CDK13, EBF3, GNAO1, GNB1, DDX3X, MEIS2, POGZ, SETBP1, UPF2, ZNF142
Data from: Effects of nicotine on corneal wound healing following acute alkali burn
- 负责人：
- Kim, Jong Won
- 关键词：
- DOI：
- doi:10.5061/dryad.mk4r5
- 摘要：
- was generated by placing a piece of 2 mm-diameter filter paper soaked in 1N NaOH on the right eye. Histopathological analysis and the expression level
Data from: Evolution of neck vertebral shape and neck retraction at the transition to modern turtles: an integrated geometric morphometric approach
- 负责人：
- DOI：
- doi:10.5061/dryad.q2409
- 摘要：
- The unique ability of modern turtles to retract their head and neck into the shell through a side-necked (pleurodiran) or hidden-necked (cryptodiran) motion is thought to have evolved independently in crown turtles. The anatomical changes that led to the vertebral shapes of modern turtles, however, are still poorly understood. Here we present comprehensive geometric morphometric analyses that trace turtle vertebral evolution and reconstruct disparity across phylogeny. Disparity of vertebral shape was high at the dawn of turtle evolution and decreased after the modern groups evolved, reflecting a stabilization of morphotypes that correspond to the two retraction modes. Stem turtles, which had a very simple mode of retraction, the lateral head tuck, show increasing flexibility of the neck through evolution towards a pleurodiran-like morphotype. The latter was the precondition for evolving pleurodiran and cryptodiran vertebrae. There is no correlation between the construction of formed articulations in the cervical centra and neck mobility. An increasing mobility between vertebrae, associated with changes in vertebral shape, resulted in a more advanced ability to retract the neck. In this regard, we hypothesize that the lateral tucking retraction of stem turtles was not only the precondition for pleurodiran but also of cryptodiran retraction. For the former, a kink in the middle third of the neck needed to be acquired, whereas for the latter modification was necessary between the eighth cervical vertebra and first thoracic vertebra. Our paper highlights the utility of 3D shape data, analyzed in a phylogenetic framework, to examine the magnitude and mode of evolutionary modifications to vertebral morphology. By reconstructing and visualizing ancestral anatomical shapes we provide insight into the anatomical features underlying neck retraction mode, which is a salient component of extant turtle classification.
Data from: A tale of scale: plot but not neighbourhood tree diversity increases leaf litter ant diversity
- 负责人：
- DOI：
- doi:10.5061/dryad.v5s547r
- 摘要：
- 1. Diversity of producers (e.g. plants) usually increases the diversity of associated organisms, but the scale (i.e. the spatial area of plant diversity considered) at which plant diversity acts on other taxa has rarely been studied. Most evidence for cross-taxon diversity relations come from aboveground consumers that directly interact with plants. 2. Experimental tests of plant diversity effects on elusive organisms inhabiting the leaf litter layer, which are important for nutrient cycling and decomposition, are rare. 3. Using a large tree diversity experiment, we tested whether tree diversity at the larger plot (i.e. community) or the smaller neighbourhood scale relates to the abundance, species richness, functional, and phylogenetic diversity of leaf litter ants, which are dominant organisms in brown food webs. 4. Contrary to our expectations of scale-independent positive tree diversity effects, ant diversity increased only with plot but not neighbourhood tree diversity. While the exact causal mechanisms are unclear, nest relocation or small-scale competition among ants may explain the stronger tree diversity effects at the plot scale. 5. Our results indicate that even for small and less mobile organisms in the leaf litter, effects of tree diversity are stronger at relatively larger scales. The finding emphasize the importance of diverse forest stands, in which mixing of tree species is not restricted to small patches, for supporting arthropod diversity in the leaf litter.
Data from: Tree diversity increases robustness of multi-trophic interactions
- 负责人：
- DOI：
- doi:10.5061/dryad.847km00
- 摘要：
- Multi-trophic interactions maintain critical ecosystem functions. Biodiversity is declining globally, while responses of trophic interactions to biodiversity change are largely unclear. Thus, studying responses of multi-trophic interaction robustness to biodiversity change is crucial for understanding ecosystem functioning and persistence. We investigate plant-Hemiptera- (antagonism) and Hemiptera-ant- (mutualism) interaction networks in response to experimental manipulation of tree diversity. We show increased diversity at both higher trophic levels (Hemiptera and ants) and increased robustness through redundancy of lower level species of multi-trophic interactions when tree diversity increased. Hemiptera and ant diversity increased with tree diversity through non-additive diversity effects. Network analyses identified that tree diversity also increased the number of tree and Hemiptera species utilized by Hemiptera and ant species, and decreased the specialization on lower trophic level species in both mutualistic and antagonist interactions. Our results demonstrate that bottom-up effects of tree diversity ascend through trophic levels regardless of interaction type. Thus, local tree diversity is a key driver of multi-trophic community diversity and interaction robustness in forests.
